Stefano Fiorucci Selected Research

Interleukin-6 (Interleukin 6)

1/2023	Discovery of BAR502, as potent steroidal antagonist of leukemia inhibitory factor receptor for the treatment of pancreatic adenocarcinoma.
11/2022	Repositioning Mifepristone as a Leukaemia Inhibitory Factor Receptor Antagonist for the Treatment of Pancreatic Adenocarcinoma.
1/2022	Next-Generation Sequencing Analysis of Gastric Cancer Identifies the Leukemia Inhibitory Factor Receptor as a Driving Factor in Gastric Cancer Progression and as a Predictor of Poor Prognosis.
6/2020	Discovery of a Novel Multi-Strains Probiotic Formulation with Improved Efficacy toward Intestinal Inflammation.
10/2019	Ursodeoxycholic acid is a GPBAR1 agonist and resets liver/intestinal FXR signaling in a model of diet-induced dysbiosis and NASH.
8/2019	The Aryl Hydrocarbon Receptor (AhR) Mediates the Counter-Regulatory Effects of Pelargonidins in Models of Inflammation and Metabolic Dysfunctions.
1/2011	Probiotics modulate intestinal expression of nuclear receptor and provide counter-regulatory signals to inflammation-driven adipose tissue activation.
12/2004	Nitric oxide (NO)-releasing naproxen (HCT-3012 [(S)-6-methoxy-alpha-methyl-2-naphthaleneacetic Acid 4-(nitrooxy)butyl ester]) interactions with aspirin in gastric mucosa of arthritic rats reveal a role for aspirin-triggered lipoxin, prostaglandins, and NO in gastric protection.

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Stefano Fiorucci Research Topics

Disease

51	Inflammation (Inflammations) 12/2023 - 01/2002
27	Colitis 02/2023 - 01/2002
15	Cholestasis 01/2020 - 08/2002
13	Insulin Resistance 12/2023 - 07/2007
13	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 01/2021 - 11/2004
12	Fatty Liver 12/2023 - 04/2010
11	Neoplasms (Cancer) 03/2024 - 03/2004
10	Non-alcoholic Fatty Liver Disease 12/2023 - 11/2009
10	Fibrosis (Cirrhosis) 01/2023 - 02/2004
9	Liver Cirrhosis (Hepatic Cirrhosis) 01/2019 - 12/2003
8	Stomach Neoplasms (Stomach Cancer) 11/2023 - 01/2012
8	Obesity 01/2019 - 03/2006
7	Liver Diseases (Liver Disease) 10/2021 - 02/2002
6	Atherosclerosis 12/2023 - 01/2010
6	Pruritus (Itching) 10/2021 - 12/2014
6	Portal Hypertension 01/2016 - 12/2003
5	Body Weight (Weight, Body) 12/2023 - 09/2004
5	Biliary Liver Cirrhosis (Primary Biliary Cirrhosis) 01/2020 - 05/2009
5	Dyslipidemias (Dyslipidemia) 02/2014 - 04/2010
5	Pain (Aches) 01/2013 - 01/2006
4	Adenocarcinoma 03/2024 - 01/2016
4	Dysbiosis 12/2023 - 10/2019
4	Crohn Disease (Crohn's Disease) 01/2022 - 11/2009
4	Disease Progression 01/2020 - 05/2005
4	Hepatitis 01/2020 - 11/2009
4	Hemorrhage 01/2013 - 01/2004
3	Carcinogenesis 03/2024 - 01/2012
3	COVID-19 12/2023 - 10/2022
3	Cardiovascular Diseases (Cardiovascular Disease) 01/2022 - 06/2009
3	Acute Liver Failure (Fulminant Hepatic Failure) 01/2020 - 09/2004
3	Weight Loss (Weight Reduction) 01/2019 - 11/2004
3	Type 2 Diabetes Mellitus (MODY) 01/2019 - 07/2007
3	Rheumatoid Arthritis 12/2013 - 12/2004
3	Arthritis (Polyarthritis) 12/2013 - 12/2004
3	Necrosis 01/2012 - 02/2002
3	Glycosuria 03/2010 - 04/2004
3	Edema (Dropsy) 01/2007 - 05/2002
2	Colonic Neoplasms (Colon Cancer) 01/2023 - 10/2007

Drug/Important Bio-Agent (IBA)

40	Bile Acids and Salts (Bile Acids)IBA 03/2024 - 05/2005
33	LigandsIBA 12/2023 - 11/2004
15	Messenger RNA (mRNA)IBA 01/2022 - 01/2002
14	LipidsIBA 01/2023 - 07/2006
13	CytokinesIBA 03/2024 - 05/2003
12	CholesterolIBA 12/2023 - 02/2009
9	Glucose (Dextrose)FDA LinkGeneric 01/2022 - 04/2004
9	obeticholic acidIBA 01/2020 - 08/2002
9	Cytoplasmic and Nuclear Receptors (Nuclear Receptors)IBA 01/2013 - 11/2004
8	Sulfonic AcidsIBA 02/2023 - 01/2002
8	Interleukin-6 (Interleukin 6)IBA 01/2023 - 12/2004
7	Ursodeoxycholic Acid (Urso)FDA LinkGeneric 01/2023 - 12/2003
6	GTP-Binding Proteins (G-Protein)IBA 12/2023 - 01/2019
6	sym-trinitrobenzeneIBA 02/2023 - 01/2002
6	CollagenIBA 01/2018 - 12/2002
5	BAR502IBA 12/2023 - 01/2015
5	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 02/2023 - 01/2015
5	Proteins (Proteins, Gene)FDA Link 10/2022 - 01/2002
5	Interleukin-10 (Interleukin 10)IBA 06/2020 - 11/2002
5	AcidsIBA 02/2019 - 10/2006
5	Carbon Tetrachloride (Tetrachloromethane)IBA 01/2018 - 10/2005
5	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 01/2013 - 05/2002
5	Hydrogen Sulfide (Sulfide, Hydrogen)IBA 10/2006 - 09/2005
4	InterleukinsIBA 03/2024 - 01/2002
4	6-ethyl-3,7-dihydroxycholan-24-olIBA 12/2023 - 01/2015
4	Apolipoproteins E (ApoE)IBA 12/2023 - 10/2010
4	ChemokinesIBA 01/2023 - 10/2011
4	Acetaminophen (Paracetamol)FDA LinkGeneric 01/2020 - 02/2002
4	Insulin (Novolin)FDA Link 01/2019 - 03/2006
4	Triglycerides (Triacylglycerol)IBA 01/2017 - 02/2009
4	Ritonavir (Norvir)FDA Link 01/2014 - 10/2010
4	SteroidsIBA 01/2013 - 11/2002
4	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 05/2009 - 01/2002
4	Nitric Oxide (Nitrogen Monoxide)FDA Link 10/2007 - 11/2002
3	Leukemia Inhibitory FactorIBA 03/2024 - 01/2023
3	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 12/2023 - 01/2022
3	FructoseIBA 12/2023 - 01/2017
3	leukotriene D4 receptor (cysteinyl leukotriene receptor)IBA 01/2023 - 01/2020
3	isothiocyanic acidIBA 01/2020 - 01/2015
3	Dextrans (Dextran)FDA Link 02/2019 - 11/2004
3	Biomarkers (Surrogate Marker)IBA 01/2019 - 12/2014
3	Alkaline PhosphataseIBA 01/2019 - 12/2014
3	Dextran SulfateIBA 12/2017 - 11/2009
3	OxazoloneIBA 01/2017 - 09/2005
3	Maraviroc FDA Link 01/2016 - 05/2013
3	Cadherins (E-Cadherin)IBA 01/2016 - 01/2013
3	Protease Inhibitors (Protease Inhibitor)IBA 01/2014 - 01/2012
3	Pregnane X ReceptorIBA 12/2013 - 05/2009
3	Chemokine CCL5IBA 12/2013 - 10/2011
3	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA 01/2013 - 04/2004
3	Rifaximin (L 105)FDA Link 10/2011 - 01/2002
3	Cyclooxygenase 2 Inhibitors (COX-2 Inhibitors)IBA 06/2009 - 01/2004
3	sodium bisulfide (NaHS)IBA 10/2006 - 09/2005
3	Peptide Hydrolases (Proteases)FDA Link 07/2006 - 11/2004
3	2- methyl- 3- (2- ((4- nitrooxybutyloxy)carbonyl)vinyl)phenyl ursodeoxycholic acid esterIBA 09/2004 - 12/2003
2	Atorvastatin (Lipitor)FDA Link 12/2023 - 01/2022
2	ApolipoproteinsIBA 12/2023 - 12/2023
2	Glucagon-Like Peptide 1 (GLP 1)IBA 12/2023 - 01/2022
2	RNA (Ribonucleic Acid)IBA 11/2023 - 01/2022
2	OSM-LIF ReceptorsIBA 01/2023 - 01/2022

Therapy/Procedure

18	Therapeutics 03/2024 - 05/2002
4	Ligation 01/2020 - 02/2004